Fighting the global health threats posed by COVID-19

While all continents are now affected by the COVID-19 epidemic, the research community is taking action to help populations worldwide. Here, since mid-March we have been summarising INRAE's research and structural efforts to tackle this global health challenge.

Researchers worldwide began taking action the moment the disease—since named COVID-19 by the WHO—emerged in China. COVID-19 is caused by a virus that affects the respiratory system. Chinese scientists quickly sequenced the virus to determine its identity. It belongs to the coronavirus family and has been designated SARS-CoV-2. A different member of this same family caused an epidemic in China in 2002–2003. We now know that SARS-CoV-2 is closely related to a virus found in bats. It might have spilled over into humans by way of an intermediate host. At present, there are no medications, vaccines, or antibody-based methods that can be used in the fight against SARS-CoV-2. Consequently, current measures focus on limiting virus transmission within human populations. The entire international research community is working to address this global health crisis. INRAE is specifically involved in numerous efforts:

All the news

Fighting the virus and treating its victims

"We are using high-quality research to stem the spread of SARS-CoV-2 and to help treat those infected"—French National Alliance for Life Sciences and Health (AVIESAN)

INRAE NEWS

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Q&A with Muriel Vayssier-Taussat, CARE member: what comes after the lockdown
News, 2 April. The Council for Analysis, Research, and Expertise (CARE), established by the French government on 24 March 2020, comprises a group of 12 researchers and medical doctors with different specialties. CARE is tasked with quickly providing guidance to the French government on matters related to coronavirus treatment and testing. Muriel Vayssier-Taussat, the head of INRAE’s scientific division for animal health and director of the Carnot Institute Livestock Industry for the Future, describes her first experience on the council.

COVID-19: Tackling the Epidemic in 20 Research Projects...
Press release – published on 12 March 2020
At a time when the Sars-CoV-2 epidemic is continuing to spread, France’s Alliance for Life Sciences and Health (Aviesan) is mobilizing to accelerate research into the virus and COVID-19 disease through REACTing – a consortium coordinated by Inserm.
…including a research project conducted by INRAE to test drug candidates:

Matériel de laboratoire

SARS-CoV2: INRAE’s research community in the Île-de-France region is mobilising
News, 3 April. As the COVID-19 epidemic spreads throughout the world, the research community is mobilising its forces. In the Paris region, INRAE researchers Jean-François Eléouët and Bernard Delmas and their teams in the Molecular Virology and Immunology Unit (VIM) are hard at work: their aim is to accelerate their knowledge, prevent and cure the disease; each new goal corresponds to a new research project.

IN BRIEF

20 April.  Covid-19: launch of an international survey on loss of sense of smell and taste
Many COVID-19 patients experience a loss of taste or their sense of smell. More than 400 scientists from 52 countries have come together to study this phenomenon as part of the Global Consortium for Chemosensory Research (
GCCR). More than 35 French researchers, in particular in INRAE units, are taking part. The consortium launched a large-scale international survey in the form of a short questionnaire (currently available in 14 languages) aimed at people who are currently sick with COVID-19 or who have now recovered. The researchers’ priority is to assess the frequency and nature of the loss of taste or sense of smell among the persons affected, to compare them with other pathologies (influenza, common cold, etc.) and to initiative medium and long term monitoring.

Mitigating the risks of the epidemic

“With climate change, animal and human mobility, growing populations and urbanisation, there is now an increased risk of the emergence and accelerated global spread of new pathogens. It is crucial that the emergence of a pathogen can be rapidly detected and assessed for the risk it poses to public health: days and sometimes hours can count. To do so, public health agencies are developing epidemic intelligence systems” MOOD project

INRAE NEWS

📌Early calculation of actual COVID-19 fatality rate in France made possible by mechanistic-statistical model
Press Release, 12/05 - By the end of March, an INRAE team had already produced the first infection fatality ratio calculation for COVID-19 outside China. They identified a fatality rate of 0.5% based on French hospital data, adjusted to 0.8% when nursing home data were included. Their results were confirmed at the end of April by work carried out at the Pasteur Institute in Paris and by a New York study. The team’s analysis was published on 8 May 2020 in MDPI Biology.

Personne avec un masque

Strategies for confronting the COVID-19 epidemic
News, 6 April. What measures can countries take to manage a major epidemic? Sars-CoV-2, the virus causing COVID-19, has now reached every single one of the world's continents, and governments and societies are being put to the test. What strategies can we use to protect populations, control the virus's spread, prevent our health care systems from becoming overburdened, and limit the epidemic's impacts on society? Here, we discuss two main epidemic control strategies: mitigation and suppression.

Dealing with emerging diseases: rethinking how we monitor global health – INRAE is participating in the international project MOOD coordinated by CIRAD
PRESS RELEASE - published on 19 March 2020
Is disease X already here? Does the arrival of COVID-19 mean we need to rethink our health monitoring systems? As part of the MOOD project, which began in January 2020, European and North American researchers are doing just that by looking at how we might detect early signs of new epidemics.

Adopting a global approach to public health

"It is crucial to understand that the health of human populations is explicitly affected by the state of the environment” INRAE virologist Mylène Ogliastro on France 3

INRAE NEWS

Protecting biodiversity to prevent the emergence of new infectious diseases
News, 20 April. Anthropogenic activities like deforestation and the wild animal trade expose humans to new microbes. Although such microbes can pose a health threat to humans, they are an essential part of the world's biodiversity. As the loss of biodiversity continues, we are witnessing an increasing spillover of pathogens from wild animal species to humans. Research director Jean-François Guégan has great insight into this process. Currently working at INRAE, he is building a broadscale international partnership that will examine how agriculture affects the emergence of human diseases from animal or environmental sources.

📌Analysis of 65 years of work on the relationships between forests, deforestation and infectious disease emergence
Press release, 07/05. The global COVID-19 pandemic has shed light on the importance of certain previously little-studied scientific areas such as the relationships between ecosystems, their biodiversity and the emergence of new infectious diseases. Humans are making increasing use of their environment and so they are more exposed to certain microbes lurking in the shadows, a situation that may heighten the risk of new types of infection. Researchers from INRAE, CIRAD, IRD and the Pasteur Institute of French Guyana recently published in Environmental Research Letters a systematic literature review, using bibliometrics, of some 565 papers published between 1953 and 2018 on the relationships between forests, deforestation and emerging infectious diseases and noted just how scarce information on this major issue is.

📌Understanding and managing epidemics in livestock
News, 30/04. The virus causing COVID-19 appears to have jumped directly from wild animals to humans. However, in the case of other emerging pathogens, livestock have served as conduits. For example, avian influenza reached humans via such a pathway. Furthermore, many emerging pathogens are not necessarily a threat to humans but can cause serious disease in livestock, affecting both animal health and food production. What must we do to better understand and manage epidemics in livestock? We posed this question to Christian Ducrot, an INRAE epidemiologist.

Detection par immunofluorescence de cellules infectees par un virus grippal (en vert), grâce a un anticorps dirige contre la proteine non-structurale NS1, dans une culture de cellules observee en microscopie optique.

Influenza, coronavirus, and other pathogens: when animal viruses jump to humans
Zoonoses caused by viruses have plagued humans for centuries. INRAE is dedicated to finding out more about these pathogens, both those that are transmitted directly to humans and those that arrive via intermediate hosts. Avian flu, West Nile fever, and hepatitis E are just a few of the diseases studied at the institute (along with their causative agents, of course). INRAE researchers employ an approach that considers human, animal, and environmental health in tandem.
For more information, please see this
article (in French) published on February 26, 2020. It includes a video 
📽  of a conference on the topic that was held at the 2020 Paris International Agricultural Show.

Restructuring how we work during the crisis and lockdown

"We will preserve the institute's living and scientific heritage"—Philippe Mauguin in AgraPresse

INRAE NEWS

Hall INRAE

COVID-19: first assessment of the crisis plan implemented at INRAE
made by INRAE Chair & CEO in an article of 19 March

INRAE’s crisis plan for the COVID-19 epidemic in application
Article of 12 March regularly updated

FACING THE CRISIS

“This is the first time we consider the question of a food shortage in France since the Second World War! But we mustn’t confuse shortage with being out of stock because of momentary over-consumption” Vincent Chatellier, INRAE, cited in Libération

INRAE NEWS

📌COVID-19: are short food-supply chains more resilient in times of crisis?
News, 10 April. COVID-19 has caused a public-health crisis that is putting serious strains on our food systems. At the start of stay-at-home orders, there were concerns about the availability of food supplies. While long supply chains have been able to profit, a number of initiatives to support local, short food-supply chains have also emerged. What can a large-scale crisis such as this tell us about the resilience of our food systems?